Hello. I'm the Head Doctor of DIORE Clinic, Gangnam.
"I heard Rejuran is great, but there are so many types — which one should I choose?"
"What's the difference between Healer and HB? Do I need a separate eye Rejuran?"
These are questions I hear every day in the clinic. Rejuran currently comes in four product lines: Healer, i (Eye), HB Plus, and S. They all share the same core ingredient but differ in purpose and formulation. Today, I'll clearly explain the differences.
How Does Rejuran Regenerate Skin?
Rejuran's key ingredient is PN (Polynucleotide) — a biocompatible substance extracted and purified from salmon DNA. Its base composition is very similar to human DNA, making it extremely safe with virtually no immune response.
When PN is injected into the dermal layer, it activates adenosine A2A receptors, stimulating fibroblast proliferation and collagen/elastin synthesis. A 2024 study published in the Journal of Cosmetic Dermatology (Lampridou et al.) confirmed significantly increased fibroblast activity and collagen synthesis following PN exposure.
Simply put, Rejuran revives the skin's own regenerative ability rather than filling it with external substances.
Rejuran 4 Types at a Glance
| Comparison | Rejuran Healer | Rejuran i | Rejuran HB+ | Rejuran S |
|---|---|---|---|---|
| Key Ingredient | PN 20mg/mL | PN 20mg/mL | PN + HA + Lidocaine | PN 20mg/mL (high viscosity) |
| Viscosity | Medium | Low (fluid) | Medium | High (gel) |
| Target Area | Full face | Eye area | Full face | Scars/depressions |
| Key Strength | Regeneration & elasticity | Optimized for thin periorbital skin | Regeneration + hydration + pain relief | Scar regeneration & volume recovery |
| Pain | Moderate | Moderate | ~50% less | Moderate |
| Downtime | 1–2 days | 2–3 days | 1–2 days | 3–7 days |
Rejuran Healer — The Original Powerhouse
The first and most widely used Rejuran. Composed of pure PN, it focuses entirely on skin regeneration including improved thickness, elasticity, fine lines, pores, and hydration balance.
Rejuran i — Specialized for Delicate Eye Area
The periorbital skin is approximately 40% thinner than other facial areas. Rejuran i uses a lower-viscosity formulation that spreads naturally in thin skin. A study of 218 patients showed periorbital wrinkles reduced by approximately 61.4% at 12 weeks.
Rejuran HB Plus — The Pain-Free Rejuran
Combines PN with hyaluronic acid and lidocaine. Clinical trials confirmed approximately 53% pain reduction. Offers regeneration + hydration + pain relief in one treatment.
Rejuran S — High-Viscosity Scar Specialist
The 'S' stands for Scar. With the highest viscosity, this gel acts as a 3D scaffold in depressed scars. Best results when combined with subcision or fractional laser.
Which Rejuran Is Right for Me?
Overall skin improvement → Healer or HB+
Eye area focus → Rejuran i
Pain-sensitive + glow effect → HB+
Depressed scar improvement → Rejuran S
Different types can be combined by area for optimal results.
Results may vary depending on individual skin conditions. For accurate diagnosis and consultation, please consult with a qualified aesthetic medical professional.